Smoking after rabies vaccination does not usually have a significant effect, but smoking itself is harmful to health and has the risk of interfering with the immunization process, so it is recommended that you try to smoke less or even not to smoke after vaccination. Smoking is not listed as a strict contraindication in the instructions for use of the rabies vaccine, so in principle, smoking after vaccination is unlikely to have a significant effect on the immunization effect of the vaccine. However, it should be noted that smoking is hazardous to health, and prolonged heavy smoking may damage the immune system, which in turn may interfere with the production of anti-rabies virus immunity to a certain extent. Therefore, it is recommended to minimize or quit smoking after rabies vaccination to avoid interfering with the immunization process and to protect the health of the body. It should also be noted that rabies vaccine is suitable for post-exposure immunization when scratched or bitten by rabid dogs and other rabid animals, as well as pre-exposure immunization when there is a risk of exposure to the rabies virus; there are no contraindications to post-exposure immunization, whereas pre-exposure immunization is contraindicated for people who are allergic to the vaccine or those who suffer from serious chronic illnesses; there is also the possibility of headache, fatigue, vertigo, and other adverse reactions after the vaccine is administered. Therefore, those who have rabies vaccination needs must carry out standardized operations under the guidance of professional doctors, and must not blindly dispose of the vaccine on their own to avoid adverse consequences.