Bone metastases can be initially screened by doing blood tumor markers. In order to confirm the diagnosis of the disease, other items such as imaging examination and pathological examination are also needed. 1. Tumor marker test: for primary lesions, if liver cancer is suspected, alpha-fetoprotein should be checked; patients with lung cancer should have three or four tests for lung cancer, and patients with prostate cancer should be screened for PSA and so on. 2. Other examinations: such as magnetic resonance examination, CT examination, X-ray examination, pathological biopsy and so on. In order to diagnose bone metastasis, it is necessary to diagnose bone metastasis according to the results of examination, clinical symptoms and the patient’s morbidity, and cannot diagnose bone metastasis only by blood test. Patients with bone metastasis should actively seek medical treatment to avoid delaying their condition, and patients should not use medication on their own, but should cooperate with the doctor under the guidance of the doctor’s interview.