Cancer tissue has invaded into the muscular layer and plasma layer of the stomach wall, regardless of the size of the lesion or whether there is metastasis, it is called progressive gastric cancer. At present, the treatment methods of progressive gastric cancer include: What are the drugs for preoperative chemotherapy of upper gastric cancer? Preoperative chemotherapy drugs mainly include fluorouracil drugs, platinum drugs and paclitaxel drugs. This is a practical and effective preoperative treatment plan based on the available clinical research evidence, which should be measured and adjusted according to the possible adverse effects of the overall treatment plan. What does radiotherapy technology mean? The more important advancement in radiotherapy technology is the 3D conformal intensity modulated radiation therapy technology, which used to be rare in the treatment of upper gastric cancer, but now this technology has gradually matured. At what stage of upper gastric cancer patients are suitable for preoperative radiotherapy treatment? Early stage upper gastric cancer does not need preoperative radiotherapy, and surgery can be done directly; for progressive stage upper gastric cancer, that is, patients with tumor stage T3 or above or positive lymph node metastasis, preoperative radiotherapy is suitable. If abdominal metastasis has occurred, is pre-operative radiotherapy and surgery still necessary? If abdominal metastasis has occurred, it is advanced cancer and is not suitable for preoperative radiotherapy and surgery.