Patients with less severe papular urticaria usually take about 2 weeks to heal on their own, but those with more severe symptoms often do not heal easily on their own and require treatment. Papular urticaria usually presents as a soybean-sized, red, blister-like papule with blisters and no surrounding redness, with a temporary legacy of hyperpigmentation after recovery. It usually occurs on the trunk and extremities, with intense itching, and is more common in children, and may appear as pustules with fever and swollen lymph nodes if there is secondary infection. When papular urticaria occurs, it is recommended to actively apply topical and internal medications under the guidance of a doctor to minimize the duration of the disease and prevent the occurrence of hyperpigmentation, as well as to reduce the patient’s discomfort. Topical medications can be selected from lotions or emulsions with anti-itching effect for topical application, such as glycopyrrolate lotion and glucocorticoid creams. When papular urticaria is secondary to infection, antibiotic-containing drugs such as mupirocin can be applied when the exudate is not obvious, and wet compresses such as ezacrine can be used when the exudate is high. For internal medication, antihistamines with both antihistamine and sedative effects are preferred, such as Benadryl, iproniazid, chlorpheniramine, etc. taken orally, and calcium lactate or calcium gluconate tablets can also be taken orally. If there is septic infection of skin lesions, anti-infection treatment with antibiotics should be used. In addition, you can also use Chinese herbal medicine with the main purpose of dispelling wind and clearing heat for internal and external treatment. The disease is mostly related to mosquito bites, usually pay attention to environmental, living room and personal hygiene to eliminate the breeding of mosquitoes that cause the disease, you can spray insecticides that are harmless to humans inside and outside the room to eliminate fleas, mosquitoes, mites and other harmful arthropods, pay attention to avoiding the intake of allergic foods to prevent the occurrence of papular urticaria. If you do not pay attention to it in general, it may lead to prolonged or repeated attacks.