Patients with redness, swelling and blisters on the glans may be caused by mechanical stimulation, prepuce glansitis, glans herpes and other reasons. 1. Mechanical stimulation: when the patient’s glans area is subjected to mechanical stimulation, such as excessive and frequent masturbation, excessive friction of the glans due to tight clothing, etc., it may lead to the formation of localized blisters on the glans with localized redness, swelling, pain and other symptoms. 2. glans phimosis: glans phimosis is an inflammation of the mucous membrane of the glans, which is mainly manifested as localized mucous membrane edema, erythema, vesicles, ulcers, etc., and in severe cases, localized oozing, bleeding, blisters, etc. may also occur. 3. glans herpes: glans herpes is caused by human herpes virus infection, belongs to a kind of genital herpes, early can be manifested as clusters or scattered small blisters, with the development of the disease may break out to form vesicles or shallow ulcers, some patients are also accompanied by inguinal lymph node swelling and pain, fever, headache, and other systemic symptoms. Patients appear glans red, swollen, blisters, it is recommended that patients seek timely medical examination, clear causes for targeted treatment, pay attention to personal hygiene in life, keep private parts clean and dry, while patients should also dress cotton, soft, loose underwear to reduce clothing friction on the lesions, and so on.