The difference between folliculitis and syphilis lies in the following aspects: First, in terms of etiology, folliculitis is mostly due to a decrease in the immunity of the body, the inflammatory reaction caused by bacterial infections such as Propionibacterium acnes, Staphylococcus epidermidis and Staphylococcus albicans, while syphilis is a sexually transmitted disease caused by syphilis spirochete infection due to impure sexual intercourse. Second, the rash form, folliculitis can appear folliculitis papules, pustules, acne and other manifestations, syphilis in the second stage can appear folliculitis rash, can also appear similar to common psoriasis or pityriasis rose form of rash. Third, treatment, folliculitis can be topical clindamycin phosphate gel, oral minocycline hydrochloride capsules, syphilis requires intramuscular injection of benzathine penicillin injection treatment.