The addition of immunohistochemical staining for intestinal polyps does not mean that the condition is aggravated, but rather that a definitive diagnosis cannot be given under ordinary HE staining, and the combination of special staining with immunohistochemistry is needed to further assist in the diagnosis of the disease. Immunohistochemical staining is an important technique in pathological examination, the principle of which is to apply antigen-antibody specific binding to make the labeled antibody color to determine the antigen in the tissue cells, so as to locate, qualify and quantify the antigen. Immunohistochemical staining is mainly used to assist in pathologic diagnosis, assist in judging the prognosis of diseases, assist in guiding clinical use of drugs, and assist in evaluating the effectiveness of treatment. Therefore, immunohistochemistry is generally needed to determine the nature of the lesion, understand the degree of differentiation of the tumor, find the primary lesion and guide clinical treatment. Warm reminder: If immunohistochemistry is added, we need to wait patiently for the results to be returned, consult the doctor in time, and follow the doctor’s instructions for treatment.