Foreign body sensation and rice-like swelling in the corner of the patient’s eyes may be caused by blepharospasm, lacrimal caruncle inflammation, pterygium, and corneal dermatoma. Blepharospasm is a common disease in ophthalmology, which occurs in middle-aged and old people, and is related to prolonged wind and sand stimulation, bright light stimulation, aging phenomenon and other reasons. Prevalent in the inner corner of the eye and outer corner of the eye area, mostly due to conjunctival tissue degeneration and hyperplasia caused by the patient’s affected area may appear localized swelling. Lacrimal caruncle is a normal physiological structure, which is formed by the recession of the third eyelid in the evolutionary stage, and it is usually not obvious in appearance. If the patient’s lacrimal caruncle becomes inflamed, the patient can develop localized congestion and edema, which can look like the formation of rice-like flesh, as well as cause a foreign body sensation in the corner of the patient’s eye. Corneal dermatomas are usually caused by congenital developmental anomalies, and can also increase in size with age. Patients may experience a foreign body sensation in the eye, which can be surgically removed to alleviate ocular discomfort. Pterygium, on the other hand, is caused by aging. Unlike blepharospasm, pterygium grows into the corneal tissue and can be surgically removed to relieve discomfort. It is recommended that patients with a significant foreign body sensation in the eye seek prompt medical attention to evaluate their condition and follow the doctor’s instructions for treatment.