Stage 4 cancer of the liver can be treated with radiation therapy, chemotherapy, targeted therapy, and immunotherapy. All the following drugs should be applied under the guidance of doctors. 1. Radiotherapy: it is to kill cancer cells through high-energy rays and is mainly used for patients with stage 4 liver cancer that cannot be surgically resected. Commonly used radiotherapy methods include stereotactic radiotherapy and intensity-modulated radiotherapy. 2. Chemotherapy: chemotherapeutic drugs can kill cancer cells and prevent their growth, and can be taken orally or used intravenously. Commonly used chemotherapy drugs include gemcitabine, oxaliplatin, cisplatin and so on. 3. Targeted therapy: This therapy can target cancer-causing mutations and is an important therapy for advanced liver cancer patients. Commonly used drugs include Sorafenib, Lenvatinib, Regorafenib and so on. 4. Immunotherapy: it can improve the patient’s own immune function, so as to recognize and kill cancer cells more effectively. At present, the main applied drugs are pabolizumab, nabulizumab and so on. Patients with stage 4 liver cancer need to go to the hospital in time to get a clear diagnosis and treatment plan, use drugs under the guidance of doctors and avoid self-medication.