Low white blood cells in patients with chronic granulomas firstly cannot stop the drug on their own, secondly, they should prevent infections, and add white blood-boosting drugs or switch to targeted drugs under the guidance of the doctor, and they also need to be further examined in detail to exclude the progression of the disease. In the course of treatment, especially at the beginning of treatment, due to the inhibitory effect of drugs on the bone marrow, there are abnormalities in the blood routine and a decrease in the white blood cell index. 1. When the white blood cells are abnormal, the neutrophil count should be paid attention to. If the neutrophil count is lower than 1.0×10⁹/L, it is necessary to contact the attending physician in time for drug adjustment. 2. Granulocyte colony-stimulating factor (GCSF) can also be added to elevate the white blood cells, and at the same time, the blood routine should be closely reviewed. 3. If the degree of hematopoiesis is low and there is no obvious symptom of trilineage reduction, the current treatment can be continued. Drugs include imatinib, etc. It is recommended that patients go to the hospital in time, under the guidance of specialized physicians, so as to avoid delaying the condition.