Vonorasan fumarate tablets with amoxicillin should also be combined with an antibiotic and a bismuth agent in order to be effective in eradicating H. pylori. The most commonly used method to eradicate H. pylori is quadruple therapy, i.e., two antibiotics, a proton pump inhibitor, and a bismuth agent. Proton pump inhibitors are drugs that inhibit the secretion of gastric acid, while vonorasone fumarate tablets are a new type of acid-suppressing drugs that can replace proton pump inhibitors to inhibit the secretion of gastric acid, which in turn can be used to treat reflux esophagitis and other diseases. Therefore, vonorasan fumarate tablets and amoxicillin should also be combined with an antibiotic, a bismuth agent in order to play a role in the eradication of Helicobacter pylori, such as vonorasan fumarate tablets with amoxicillin, metronidazole, and bismuth potassium citrate. It is important to note that it is contraindicated in patients who are allergic to any of the components of vonorasan or who are being treated with atazanavir or rilpivirine; adverse reactions such as nausea, constipation, and rash may occur with the drug. Penicillin therapy is contraindicated in patients who are allergic to any penicillins; adverse reactions such as anaphylactic reactions and serum sickness-like reactions may occur after administration. Patients who need to use Vonorasan Fumarate Tablets in combination with Amoxicillin should be under the guidance of a doctor.