Patients with cranial defects often have a heavy burden of thought such as insecurity, and can cause headache, dizziness, fear of vibration and other syndromes. The longer the cranial defect, the higher the incidence of cranial defect syndrome and secondary brain damage. In order to restore the airtightness of the cranial cavity, keep the physiological intracranial pressure stable, and reduce the cranial defect syndrome. Cranial bone repair should be performed for cranial defects with a diameter of more than 3 centimeters, without muscle coverage, and without contraindications. Cranial repair is a relatively routine procedure in neurosurgery, and according to the neurosurgical guidelines for cranial repair, children can have this surgery after they reach three years of age. The reason is that after the age of three, the child’s skull basically grows more slowly, and the skull grows along the bone seam, so the size of the bone window basically does not change much. Moreover, the child is in the age of active, self-protection consciousness is not strong, easy to be hurt by the outside world; long-term cranial defects, it is also easy to cause neurological damage: so the need for early cranial bone repair surgery. Of course, to do skull repair, repair materials need to be carefully selected, has been used to repair the skull of many materials, such as animal bones, plexiglass, and now widely used in clinical titanium mesh, titanium mesh compared to the previous repair material performance has been greatly improved and enhanced, but there are still some problems, clinical use of titanium mesh materials for repair found that the patient is extremely susceptible to postoperative infection, rejection, and may even have a titanium mesh repair. The clinical use of titanium mesh material for repair found that patients are extremely susceptible to postoperative infection, rejection, and even the possibility of titanium mesh exposure, so titanium mesh is not a more suitable repair material for cranial bone repair. Currently, polyether ether ketone PEEK material is a kind of ideal material with excellent performance. peek material is a kind of polymer material, according to the patient’s cranial CT data for three-dimensional reconstruction before the operation, highly restore the anatomical structure of the skull, precise anastomosis of the defective area, and this material can be fused with the autologous skull, all in one, and all the performance is very good, it’s a very good cranial bone repair material.