Pain in the upper part of the chest can be caused by the following diseases: First, patients with intrapulmonary infections, repeated coughing and coughing up sputum, can also experience chest pain, especially pinprick-like pain in the mural pleura involved. Active intravenous anti-infection treatment can gradually improve the patient’s symptoms. Secondly, costochondritis occurs mainly in young people, with more female patients than male, and the patient presents with pain in the anterior thoracic 2nd-4th rib cartilage area, that is, pain in the upper part of the chest. The pain can be aggravated after activity or exertion, and some patients also have persistent pain, which can be treated with pain relief. Thirdly, some patients have diseases in the thoracic cavity or mediastinum, and patients with mediastinal cysts gradually increase in size, which may also manifest as chest pain, and even aggravate chest tightness after activity, and need to choose surgery if necessary.