The discomfort of the knee after running is considered to be related to strenuous exercise, incorrect running posture and other physiological factors, and does not require special treatment. It is also considered to be related to knee osteoarthritis, meniscus injury, etc., and can be treated with medication or surgery as prescribed by the doctor. 1. Physiological factors: strenuous exercise, incorrect running posture, etc. can cause discomfort in the knee after running. Usually there is no need for special treatment, and the discomfort will be relieved after proper rest. 2. Knee osteoarthritis: In the acute stage, it is necessary to pay attention to rest, reduce the weight of the joints, but also through the ice to ease the swelling. The pain can be relieved with non-steroidal anti-inflammatory drugs such as celecoxib and etoricoxib as prescribed by the doctor, and some patients can be injected with glucocorticoids and sodium vitrate by puncture into the joint cavity. Arthroscopic cleaning, osteotomy, joint fusion and other surgical treatments are feasible in severe cases. In addition to the above treatments, some patients with knee osteoarthritis can also use hydrotherapy, cold therapy, heat therapy, transcutaneous electrical nerve stimulation and other physical therapy, but also with the help of crutches, joint supports and other assisted movement. 3. Meniscus injury: acute patients need to stop activities, as soon as possible ice or gauze pressure bandage, pain can also use ibuprofen, indomethacin and other non-steroidal anti-inflammatory drugs to relieve. Some patients with serious conditions can also feasible meniscus suture surgery, meniscoplasty, meniscus replacement surgery and other surgical treatments. After running knee discomfort is also associated with rheumatoid arthritis, fractures, ligament injuries, etc., it is recommended to consult a doctor for examination, in order to clarify the cause of the disease and then follow the doctor’s instructions for treatment.