You can still run with a missing big toe. When running and walking in daily life the forefoot will be involved in the force, although the big toe as part of the forefoot also needs to be stressed, but the other toes can also be used as a point of force to run, so the missing big toe can still run. Missing big toes will have some impact on balance and foot function, but it does not have much effect on daily walks, walks, jogging and other non-strenuous sports. However, it should be noted that if you are doing more strenuous, weight-bearing sports such as sprinting competitions and jumping sports, these exercises should be avoided as much as possible so as not to cause falls due to body imbalance. Patients with missing big toe should pay attention to the daily maintenance of the body to avoid falls and injuries, and go to the hospital in a timely manner, under the guidance of the doctor for treatment, so as not to miss the best treatment period, affecting the health of the body.