The limited clinical data available suggests that both amoxicillin and cephalosporin are relatively safe for use in pregnant women and do not increase the risk of congenital malformations or other abnormalities. Pregnant women are advised to use them cautiously under the supervision of a physician, weighing the pros and cons. Amoxicillin has antimicrobial activity against Streptococcus pneumoniae, Streptococcus hemolyticus, non-penicillinase-producing staphylococci, Enterococcus faecalis, Escherichia coli, Aspergillus chrysosporium, Salmonella spp, Haemophilus influenzae, Neisseria gonorrhoeae, and Helicobacter pylori. Adverse reactions to amoxicillin include: symptoms of allergic reactions, such as drug fever, urticaria, rash, asthma, etc.; digestive reactions, such as diarrhea, nausea and vomiting, etc.; blood abnormalities, such as eosinophilia, leukopenia and thrombocytopenia, etc.; abnormalities of hepatic and renal function, such as elevated serum aminotransferase, etc.; and others, such as symptoms of euphoria, anxiety, insomnia and dizziness. Cephalosporins, depending on the species, generally have antibacterial activity against staphylococci, Streptococcus pyogenes, Diplococcus pneumoniae, diphtheria bacilli, S. pneumoniae, S. pyogenes, S. influenzae, and so on. Common adverse reactions to cephalosporins include allergic reactions, such as rash, urticaria, drug rash, eosinophilic leukocytosis, etc.; liver and kidney impairment, gastrointestinal discomfort and other symptoms. If there is a need to use amoxicillin and cephalosporin pregnant women, it is recommended to consult a professional doctor, follow the doctor’s instructions to standardize the treatment, not blindly self-medication.