Esomeprazole has a stronger acid-suppressing effect than rabeprazole, and the cost of esomeprazole is also much higher compared to rabeprazole. But as to which drug works well, it varies from person to person, and the one that suits you is the best. It is not necessarily the highest cost drug that is the best drug. For patients with gastric ulcer or gastritis, proton pump inhibitor therapy is generally preferred, which is often referred to as omeprazole, rabeprazole, etc. Esomeprazole is a relatively new drug, so the current cost is also relatively high. It is recommended that patients need to start with the most basic drugs, such as the first generation omeprazole can be tried first. If the effect is not satisfactory, only then can you consider changing to other proton pump inhibitors, the specific need to consult a specialist.