Fever is one of the body’s self-protection mechanisms, antipyretic drugs can not target disease treatment, but can relieve symptoms. Some parents are anxious and add medication frequently when they find that their child’s temperature has not decreased significantly after giving medication, which is incorrect. Children’s body temperature can vary with age, gender, and race, and is affected by day and night, seasonal changes, etc. Mild fever itself is not dangerous, so it is usually not recommended to use antipyretic drugs when the temperature is below 38.5°C, the mental state is still good, and the study and work are not affected. At this time, physical cooling methods can be used, including taking a warm bath or wiping the body with a warm wet towel, along with proper hydration. When the body temperature exceeds 38.5°C, antipyretic drugs may be considered as an option. Paracetamol and ibuprofen are relatively safe for pediatric patients, but care should be taken not to overdose. Ibuprofen has a strong antipyretic effect, but it can lead to profuse sweating and even deficiency, and is not suitable for children with diarrhea and dehydration. Most antipyretics work within two hours, and the average time of onset of action is about one hour after taking the medicine. If parents find that their children start to sweat, cry less or have a better mental state after taking the medicine, it proves that the medicine has started to work, so don’t rush to add or change the medicine. Generally every 6-8 hours, the shortest interval between doses is 4 hours, if used too often, it may cause liver and kidney damage. It is better to change one kind of antipyretic medicine under the guidance of a doctor for more than 3 days in a row to prevent the accumulation of side effects. It is better to use only one kind of antipyretic medicine, because the risk of using the wrong medicine doubles with each additional medicine. Also, once an adverse drug reaction occurs, it is difficult to identify which drug is responsible. Many people think that the faster and lower the temperature recedes after taking antipyretic drugs, the better, which is a misconception. The ideal fever-reducing effect is mild, with the body temperature falling below 38.5°C. It is important to be properly hydrated, as this will speed up excretion and facilitate the reduction of fever. Also pay attention to loose, breathable clothing, do not cover the thick quilt, to prevent fever convulsions. It should be reminded that the duration of fever in children is generally 3 to 5 days, and can be relieved with medication according to the condition. However, if the fever is not relieved after the medication, or even other symptoms appear, you should seek medical attention promptly.