Heel blisters usually do not require special treatment, and it is sufficient to avoid further friction. If there is a secondary bacterial infection, the patient should follow the doctor’s instructions to take appropriate treatment. If the foot is rubbed for a long time, or the shoes do not fit properly, it may lead to edema and oozing of the local skin tissues, resulting in the appearance of heel blisters. Generally, these symptoms can be relieved by themselves as time progresses. In the meantime, avoid friction and squeeze the heel. When the local skin secondary infection, redness, swelling, pain, exudate pus and other symptoms, you need to use antibiotics under the guidance of the doctor, such as mupirocin ointment, fusidic acid cream and so on. Or oral amoxicillin, cefaclor and other antibiotics, after standardized drug treatment, can improve the prognosis. Meanwhile, for infected blisters, they should be cleared regularly and treated with medication changes. If the patient has a heel blister, you can go to the regular hospital, relevant examination, under the guidance of the doctor to take relevant therapeutic measures.