Gallbladder cholesterol crystals usually have no clinical symptoms and do not cause abdominal distension, but if they develop into stones or polyps and cause inflammation, they may show corresponding symptoms, such as abdominal distension, nausea, vomiting and fever. The development of cholesterol crystals into stones or polyps may cause the contraction and excretion function of the gallbladder to be affected, which may lead to cholecystitis, with digestive symptoms such as nausea, vomiting, and abdominal distension. The formation of cholesterol crystals is mainly related to the relatively small amount of bile acids and the excessive precipitation of cholesterol. If the cholesterol crystals are small and do not cause clinical symptoms, ultrasound can be performed periodically. If the crystals are large and affect the contraction and excretion of the gallbladder, they can be treated with oral ursodeoxycholic acid or surgical removal. The use of drugs should be under the guidance of a doctor, and if recurrent cholecystitis occurs, surgical treatment should be considered.