Differential diagnosis of congenital factor X deficiency

Congenital factor X deficiency: This disease is extremely rare, is autosomal recessive, is often inherited from inbred parents, and can develop in both sexes. Because factor X can involve the function of both intrinsic and extrinsic coagulation systems, it can also have similar symptoms to factor VII deficiency, and the degree of bleeding is related to the concentration of factor X. The heterozygous type generally has bleeding symptoms, while the heterozygous type can have no bleeding tendency with a factor X concentration between approximately 20% and 50%. Laboratory tests, prothrombin time (PT), partial thromboplastin time (PTT) and snake venom time are prolonged, the latter can be differentiated from factor VII deficiency. Treatment is based on factor X supplementation, using stored plasma, PPSB or a concentrated preparation of factor X. 10-15 ml of plasma per kg of body weight is infused. The effective hemostatic concentration of factor X is about 5% to 10%. The hemostatic concentration for severe bleeding is about 15% to 20%. What are the easily confused symptoms? Hemophilia A Hemophilia A (HA) is a recessive hereditary bleeding disorder caused by X-chromosome-linked abnormalities in the amount and molecular structure of coagulation factor VIII. It is characterized by “spontaneous” joint bleeding and deep tissue bleeding. 2. Hemophilia B Hemophilia B (HB) is a hereditary disease with a similar inheritance pattern and bleeding manifestations as hemophilia A. Its pathogenesis is a deficiency of factor IX. Vitamin K is a fat-soluble vitamin containing a homologue of 2-methyl-1,4-naphthoquinone, a synthetic compound without side chains, which is fat-soluble and its derivatives are soluble in water. As an “anti-bleeding vitamin”, vitamin K is essential for the synthesis of prothrombin and other clotting factors in the liver. Naturally occurring vitamin K is a yellow oil; synthetically it is a yellow crystalline powder. All vitamin K is resistant to heat and water, but is susceptible to damage by acids, bases, oxidants, and light (especially ultraviolet light), and vitamin K deficiency is a set of symptoms that manifests itself as a vitamin K deficiency. Vitamin K deficiency is a coagulation disorder caused by a lack of vitamin K. 4. systemic lupus erythematosus (SLE) is an autoimmune disease that involves multiple systems and organs and has multiple autoantibodies. Tissue damage is caused by the presence of a large number of pathogenic autoantibodies and immune complexes in the body. Clinical manifestations may include damage to various systems and organs, such as the skin, joints, plasma membranes, heart, kidneys, central nervous system, and blood system. The disease occurs worldwide, with a prevalence of 4/100,000 to 25/100,000, with a higher prevalence in Asia and blacks, and a prevalence of 70/100,000 to 75/100,000 in China. The incidence is significantly higher in women than in men, about 10:1, with a peak in women of childbearing age, and in the elderly and children. The disease belongs to the category of yin and yang poison, yang poison hair spot, butterfly spot, sun sore, ghost face sore, face travel wind and other diseases in Chinese medicine.