Myeloma chemotherapy does not usually cause urinary retention. Common adverse reactions of myeloma chemotherapy include digestive symptoms such as constipation, diarrhea, nausea and vomiting, which can also cause a transient decrease in platelets, and side effects such as herpes zoster, peripheral neuritis, fatigue and weakness, and itchy rash and infections in some patients, which generally do not cause urinary retention. There are many reasons for urinary retention, such as cerebral dysfunction, cerebrovascular disease, spinal cord trauma, urinary system tumors, etc.; patients should under the guidance of the physician to do the relevant examinations, such as bladder ultrasound, routine urine examination, routine blood test, etc., to further confirm the diagnosis and choose the treatment measures. Myeloma patients or myeloma chemotherapy after the occurrence of urinary retention need to actively consult the doctor, the patient should not self-medication, under the guidance of the doctor’s consultation in accordance with the standard treatment.