Blood in the stool along with mucus is most commonly associated with ulcerative colitis or Crohn’s disease, both of which have abnormal immune function and cause damage to the intestinal mucosa, and require e-colonoscopy and pathological biopsy for clarification. After the diagnosis is confirmed, medications such as mesalazine or salazosulfadiazine, plus neurontin, are needed to regulate the disease. When the symptoms are more severe, hormones such as dexamethasone or prednisone are also needed to treat the disease for a lifetime. In addition, this disease is also seen in constipation with functional colon disease, this condition generally manifests itself as blood in the stool or dripping blood after the stool, but the mucus is mixed in the stool for a long time. This possibility should be considered if there is abdominal pain along with constipation.