Chronic atrophic gastritis c2 stage belongs to gastric malignant tumor precancerous lesions, but do not need to be too afraid, through the systematic treatment, protection of gastric mucosa, anti-Helicobacter pylori infection and other treatments can be prevented from disease progression. Chronic atrophic gastritis closed atrophy with C represents, divided into C1, C2, C3 three stages, c2 stage is a type of atrophic gastritis, said the degree of gastric mucosal atrophy, no deterioration does not terrible. Chronic atrophic gastritis c2 stage can be given omeprazole, thioglycollate and other gastric mucosa protection treatment. If Helicobacter pylori is present, quadruple therapy can be given, such as amoxicillin, clarithromycin, colloidal bismuth pectin, esomeprazole and other drugs. Daily attention should be paid to avoiding foods that irritate the gastric mucosa and eating easily digestible foods. Chronic atrophic gastritis C2 stage is recommended to actively consult the doctor, under the guidance of the physician standardized treatment, to control the progress of the disease.