There is no allopurinol and benzbromarone tablets which effect is good, the two in the pharmacological mechanism, adverse reactions and contraindications of drugs and other aspects of the differences, should be selected according to the needs of the disease. 1. Pharmacological mechanism: allopurinol is a kind of inhibition of xanthine and hypoxanthine metabolism known as uric acid to play a role in lowering uric acid; Benzbromarone mainly through the inhibition of renal tubular reabsorption of uric acid to play a role in lowering uric acid. 2. Adverse reactions: allopurinol common adverse reactions include leukopenia, alopecia, gastrointestinal reactions and rash; benzbromarone common adverse reactions include itching, erythema, swelling, liver biochemical index abnormalities and gastrointestinal reactions. 3. Contraindications: Allopurinol is contraindicated in patients who are allergic to the drug components, obviously low blood cells, severe hepatic and renal insufficiency, as well as lactation or pregnancy; Benzbromarone is contraindicated in patients with moderate to severe renal insufficiency, allergic to the drug components, and lactation, pregnancy. Allopurinol and Benzbromarone are both uric acid-lowering drugs, and are not recommended for use during an acute attack of gout. Allopurinol and benzbromarone tablets should be used under the guidance of a physician, it is recommended that patients to the rheumatology and immunology department of the regular hospital for detailed consultation and compliance with medication.