The following matters should be noted when taking sulfonamides: 1. Double the first dose to rapidly reach the antibacterial concentration, and then use the maintenance amount. 2. Drink more water and take baking soda tablets at the same time because the metabolites of sulfonamides tend to form crystals in acidic urine and increase in solubility in an alkaline environment. Therefore, they should not be taken together with acidic drugs, such as vitamin C, amyl chloride, pepsin combination, etc. 3. Sulfonamides used for a long time can cause granulocytopenia, thrombocytopenia, and aplastic anemia. Therefore, the blood routine should be monitored during the use of drugs. It can also cause liver and kidney function damage, and liver and kidney function should also be monitored during drug use. Sulfonamides have a high risk of allergic reactions, such as erythema multiforme and epidermal necrolysis relaxation rash, and should be used with caution by allergic individuals.