Multiple small retroperitoneal lymph nodes are not necessarily caused by metastasis. For retroperitoneal multiple small lymph nodes, there may be their own bacterial, viral infection caused by inflammation, causing lymph node enlargement, as well as the patient’s own existence of some immune system diseases, and there may also be hematologic diseases. For example, lymphoma, leukemia, but can not be ruled out is a malignant tumor through the lymphatic tissue metastasis caused by retroperitoneal multiple small lymph node enlargement. In this case, patients are usually advised to undergo pet CT, which can clarify the presence of early atypical malignant tumors. Subacute lymph node biopsy can also be performed to clarify the cause of lymph node enlargement. If you find multiple small retroperitoneal lymph nodes, please go to a regular hospital in time, listen to the professional doctor’s opinion, and actively diagnose and treat them, so as to avoid delaying your condition.