Cerebral infarction hemiplegia, a type of hemiplegia caused by cerebral infarction, in which patients may present with hemiplegia or immobility, is seen in patients with large hemispheric infarcts and basal ganglia infarcts. Patients with large hemispheric infarcts may present with hemiparesis, hemianesthesia, and may also develop impaired consciousness and, in severe cases, cerebral edema and increased intracranial pressure. Their treatment mainly includes patients in the ultra-early stage, and thrombolysis should be tried if it is suitable. In case of unsuitable thrombolysis and beyond the time window of thrombolytic therapy, aspirin should be given as early as possible to anti-platelet aggregation, along with neuroprotective and circulation improvement therapy, and also butylphthalide to improve the signs and symptoms of neurological deficits. If the patient’s condition is stable, rehabilitation should be given as early as possible. If patients have impaired consciousness, they should be given brain-awakening treatment, and the main drugs include brain-awakening sedation. If the patient has increased intracranial pressure, cranial pressure-lowering therapy should be given, mainly applying mannitol, glycerol fructose and tachypnea. If the patient has an infarction of the vertebrobasilar system, there is usually no impairment of consciousness and no cerebral edema, and the treatment of this disease is mainly to give anti-platelet aggregation, neuroprotection, and protection of mitochondria.