A liver surface that is less than smooth with a perihepatic effusion may indicate the presence of cirrhosis and a small amount of peritoneal fluid in the patient. Cirrhosis is a common diffuse liver damage in clinic, and the liver often shows nodular surface, not smooth, lobe disproportion, uneven liver density, lobe atrophy, and widened hepatic fissure; when there is perihepatic fluid and splenomegaly, it often suggests that there are manifestations of portal hypertension. Therefore, when there is a lack of smooth liver surface and perihepatic effusion, patients need to complete the imaging and liver function tests in time to determine whether there is cirrhosis, and if the diagnosis is confirmed, timely treatment is needed. When the liver surface is not smooth perihepatic effusion, it is necessary to consult a doctor in time, complete the relevant examinations, and carry out standardized treatment under the guidance of the doctor.