Different thoracic spine tuberculosis drugs are taken in different ways, such as rifampicin needs to be taken on an empty stomach, pyrazinamide, isoniazid and so on are generally recommended to be taken on an empty stomach, and can also be taken after meals, when gastrointestinal problems are recommended to be taken after meals. For patients with thoracic spine tuberculosis, the first-line antituberculosis drugs that can be used in accordance with medical advice are pyrazinamide, rifampicin, isoniazid and other treatments. Rifampicin is recommended to be taken on an empty stomach, but anti-tuberculosis drugs are prone to cause some adverse reactions in the digestive tract, so for people who have a weak stomach, other tuberculosis drugs, such as pyrazinamide and isoniazid can also be taken after meals. Thoracic spine tuberculosis patients should pay attention before using drugs, the use of anti-tuberculosis drugs may cause some adverse reactions, such as pyrazinamide can cause liver damage, rifampicin can cause gastrointestinal symptoms, isoniazid can cause peripheral neuritis, liver dysfunction and so on. Regardless of the type, or types of anti-tuberculosis drugs one is using, the first thing to note is that they must be contraindicated in case of allergy to the drugs. The use of anti-tuberculosis drugs should be early, regular, throughout the whole process, the right amount of the principle. Patients with thoracic spine tuberculosis should cooperate with their doctors to use individualized medication treatment plans suitable for them, and should not abuse drugs.