Small blisters on the soles of the feet should be selected according to the cause of the drug, if it is tinea pedis, you can use topical terbinafine ointment, clotrimazole ointment; eczema, you can use zinc oxide ointment, hydrocortisone cream; allergic factors, you can use compound dexamethasone ointment, fludioxonium acetate cream and other glucocorticoid ointment. 1. Tinea pedis: It is caused by fungal infection of the superficial skin of the feet, and blister-type tinea pedis will cause small blisters on the soles of the feet. You can use topical terbinafine ointment, clotrimazole ointment and other antifungal drugs to treat it. 2. Eczema: Inflammatory skin reactions caused by internal and external stimuli may cause eczema on the soles of the feet, resulting in small blisters, itching and other symptoms. Zinc oxide ointment and hydrocortisone cream can be used. 3. Allergic factors: contact dermatitis, drug rash and other allergic factors may also lead to plantar skin erythema, small blisters on the soles of the feet, itching and other symptoms. You can use boric acid solution wet compresses, compound dexamethasone ointment, fluoride acetate easy cream and other glucocorticoid ointment. Small blisters on the soles of the feet should be timely medical attention, all drugs need to be used under the guidance of a professional doctor.