Glucocorticoids have anti-inflammatory, anti-rheumatic, and immunosuppressive effects and are sometimes used to treat some kidney diseases. Short-acting hormones include: hydrocortisone, cortisone. Intermediate-acting hormones include: prednisone (prednisone), prednisolone, methylprednisolone, and deferiprone. Long-acting hormones include: dexamethasone, betamethasone and other drugs. Many patients are confused and nervous when it comes to glucocorticosteroids, hoping to get rid of the disease on the one hand and fearing its adverse effects on the other. So what should we know about glucocorticoids? The following is an introduction to the adverse effects of glucocorticosteroids and precautions for their use. The adverse reactions of glucocorticosteroids are obviously related to the type, dose, course, dosage form and usage of the drug. During the use of glucocorticosteroids, the adverse reactions should be closely monitored, such as infection, abnormal water and electrolyte metabolism, abnormal blood sugar and lipid, weight gain, bleeding tendency, abnormal blood pressure, osteoporosis, femoral head necrosis, etc. The growth and development of children should be monitored. The following basic matters should be noted when using glucocorticoids: 1. Generally take them in the morning or as prescribed by the doctor. 2. Pay attention to the presence or absence of water and sodium retention: e.g. facial as well as lower limb edema. Hypertension. 3. Pay attention to the presence of infection such as fever, cough, etc. 4. Pay attention to proper diet control and blood sugar monitoring to prevent the occurrence of diabetes. 5.Appropriate calcium supplementation to prevent osteoporosis. 6, pay attention to the presence of gastric bleeding and other gastrointestinal symptoms, observe the stool situation. 7, long-term use of hormones skin manifestations are: Cushing’s syndrome-like face, centripetal obesity, facial erythema, acne, etc. 8, pay attention to the presence of glaucoma. 9, hormones can not be discontinued without authorization, under the guidance of a specialist to gradually adjust the dose, the appropriate time to reduce the dose until the drug is discontinued. 10.After discharge from the hospital, go to the specialist clinic for regular review.