Crescent body formation is a characteristic pathological change in crescent body nephritis, which usually results in rapid deterioration of renal function and is common in acute progressive glomerulonephritis. Crescent body nephritis is one of the most severe morphological changes in the glomerular inflammatory response. Renal pathology is characterized by pathologic changes on both light and electron microscopy. Proliferation of epithelial cells in the glomerular wall layer accumulates, monocytes and lymphocytes infiltrate, and may form a crescent-shaped or ring-shaped structure called crescent body around the capillaries, with cellular crescent in the early stage and fibrous crescent in the later stage. The condition of this disease is critical and the prognosis is poor, but if the diagnosis can be clarified early and the correct treatment can be taken in time according to the different causes, the prognosis can be clearly improved. Patients with crescent body formation should seek timely medical treatment and standardize the treatment under the guidance of professional doctors.