Edward’s syndrome is a disease caused by chromosomal abnormality, also known as trisomy 18, due to an extra chromosome 18, which may abnormally cause the patient to have multiple organ malformations, which can be manifested in the head, limbs, genitalia, nervous system, heart and other parts of the body.1. Head: such as protruding posterior occipital bone, low malformed ears, small jaw, small eye clefts, wide eye spacing, ptosis of the upper eyelid, canthus, small eyes, hypertonia, and small mouth may be accompanied by cleft lip or cleft palate. small, hypertonia, small mouth can be accompanied by cleft lip or cleft palate; 2, limbs: a special fist shape, 3, 4 fingers close to the palm of the hand, 2, 5 fingers pressed on it, 1/3 of the through the palm, rocking chair-like feet; 3, genitalia: male patients commonly cryptorchid testis, female patients often labia majora or clitoral dysplasia; 4, neurological: can be seen in mental retardation, hypertonia; 5, cardiac: 95% of the patients are accompanied by congenital Cardiac malformations, mainly ventricular septal defect and arterial atresia insufficiency, which is the main cause of death; 6, other: abdominal muscle defects are often seen in umbilical hernia, inguinal hernia, renal malformations including polycystic kidneys, ectopic kidneys, horseshoe kidneys and so on. In addition, patients are accompanied by growth and development disorders, which can be manifested as low birth weight. In addition, patients also have abnormal growth retardation, and often have difficulty in eating and breathing due to abnormal organ morphology.