Indirect bilirubin and alanine aminotransferase are high according to the causes of drug hepatitis, viral hepatitis B, fatty liver, etc. Drugs such as dicyclomine, entecavir, orlistat, surgical treatment, etc. can be given. 1. Drug hepatitis: drug hepatitis refers to the liver disease caused by toxic damage or allergic reaction of drugs in the process of drug treatment, due to liver function damage can appear indirect bilirubin and alanine aminotransferase high, can be given dicyclomol, thiopronin and other drugs to treat. 2. Viral hepatitis B: Viral hepatitis is a kind of infectious disease caused by hepatitis B virus infection, which can lead to high indirect bilirubin and alanine aminotransferase. It can be treated with medicines such as entecavir and tenofovir, and liver transplantation is needed when the condition is serious. 3. Fatty liver: Fatty liver is a kind of disease characterized by excessive fat storage and fatty degeneration of liver cells, often caused by alcoholism, obesity and other factors, extensive fatty degeneration of liver cells can impair liver function, and high indirect bilirubin and alanine aminotransferase can occur. Adjust the diet, reduce lipid intake, reduce weight, can apply orlistat, diammonium glycyrrhizinate and other drugs, and when the condition is serious, liver transplantation is needed. If indirect bilirubin and alanine aminotransferase are high, it is recommended to go to the hospital in time for diagnosis, improve the abdominal ultrasound, nuclear magnetic and other auxiliary examinations, and then follow the doctor’s instructions to carry out targeted treatment after clarifying the cause of the disease.