Running ankle pain and swelling may be related to insufficient warm-up, ligament injury, ankle fracture and other reasons. 1. Inadequate warm-up: when patients lack exercise for a long time, inadequate warm-up before running due to muscle inactivity, muscle stiffness, short-term running after excessive, can cause pain and swelling of the muscles around the ankle, which can be gradually relieved after rest. 2. Ligament injury: patients who run with improper force or suddenly sprain their ankles can make the ligaments suddenly in a tense state or overstretching, and then ligament injury occurs, causing pain and swelling at the ankle and wrist, and in serious cases, ligament rupture can occur, resulting in limited ankle joint activities. 3. Ankle fracture: when running under the action of external force, the ankle joint activity exceeds its normal activity load, which can also cause ankle fracture, resulting in swelling and pain in the ankle joint, and accompanied by activity disorder. Running ankle pain and swelling can also be caused by other reasons, it is recommended to go to the hospital in a timely manner, after a clear diagnosis and then standardized treatment.