High indirect bilirubin may be caused by abnormal liver function, hemolytic jaundice, autoimmune hemolytic anemia and other diseases, according to different situations can take general treatment or glutathione, azathioprine and other drugs. 1. Liver function abnormality: high indirect bilirubin may be caused by liver function abnormality, it is recommended that the patient improve the relevant examination to further clarify the diagnosis, and if necessary, can take glutathione, bicyclic alcohol and other drugs under the guidance of the doctor to protect the liver treatment. 2. Hemolytic jaundice: If the patient’s red blood cells have intrinsic defects or are damaged due to other factors, hemolysis will occur and lead to hemolytic jaundice, and high indirect bilirubin will appear in the examination. The patient needs to rest in bed, need fluids to expand blood volume, maintain water-salt and acid-base balance, and at the same time need to follow the doctor’s instructions to take azathioprine and other drugs for treatment. 3. Autoimmune hemolytic anemia: autoimmune hemolytic anemia will appear indirect bilirubin elevation, can be used under the guidance of the doctor prednisone, danazol, azathioprine and other drugs for treatment. Severe cases may require plasma exchange or blood transfusion. It should be noted that there are many other causes of indirect bilirubin elevation, and it is recommended that patients follow the doctor’s instructions to complete other related examinations to identify the cause of the disease and then symptomatic treatment.