Poststernal pain can be seen in esophageal diseases, cardiac diseases, mediastinal diseases, etc. It is recommended to consult a doctor for a clear diagnosis, and then follow the doctor’s instructions to treat the cause and symptoms. 1. Esophageal diseases: such as reflux esophagitis, esophageal cancer, etc., manifested as pinprick pain behind the sternum, accompanied by burning sensation, which is caused by esophageal tumors or inflammation stimulating the esophagus. Gastroscopy can be done after seeking medical treatment to make a clear diagnosis. For esophagitis, oral acid-suppressing gastric medication (omeprazole) can be given; esophageal cancer requires surgical treatment. 2. Heart disease: such as angina pectoris, heart attack, etc., which can cause myocardial ischemia and hypoxia and lead to retrosternal pain. It is recommended to consult a doctor to improve ECG and three items of infarction to make a clear diagnosis. Angina pectoris can be treated with oral nitroglycerin and isosorbide mononitrate; infarction requires intervention if necessary. 3. Mediastinal diseases: such as mediastinitis, mediastinal tumors, etc. Inflammation and tumors will stimulate the local mediastinum, triggering retrosternal pain and discomfort. Chest CT examination can assist in the diagnosis. Mediastinal inflammation can be treated with anti-infective symptomatic treatment (cephalosporin antibiotics); mediastinal tumor requires surgical treatment. The cause of retrosternal pain is complex, and it is recommended to consult a doctor in time and standardize the treatment. Drugs should be used under the guidance of specialized doctors.