Sore throat with pus and phlegm is mostly seen in upper respiratory tract infections caused by bacterial infections, requiring antibiotics, symptomatic and other comprehensive treatment, common medications are amoxicillin clavulanate potassium, aminoglutethimide and so on. 1. Anti-inflammatory treatment: most of the upper respiratory tract infections are caused by viral infections, and a few are caused by bacteria. There is pus and sputum presence of bacterial infection, preferred to take antibiotics, such as amoxicillin clavulanate potassium, cefixime, azithromycin, levofloxacin and so on. 2. Symptomatic supportive therapy: when there is purulent sputum, aminoglutethimide and acetylcysteine can be taken to promote sputum discharge. If necessary, nebulized symptomatic treatment such as budesonide suspension may be needed. Localized medications, such as silver yellow tablets and cediriodine tablets, can be used to relieve the sore throat. Pat the patient’s back appropriately, strengthen the drinking water and pay attention to rest. The symptoms of a sore throat with pus and phlegm are recommended to consult a doctor, and should be standardized under the guidance of the doctor’s medication.