Patients with hunger pains that are relieved by eating are most often considered to have duodenal ulcers. Patients with duodenal ulcer often have increased gastric acid, which irritates the intestinal mucosa and causes inflammatory changes in the mucosa. Alkaline foods can neutralize gastric acid and reduce the irritation of gastric acid on the mucosa and relieve pain. Duodenal ulcer is a common type of peptic ulcer, which is closely related to abnormal gastric acid secretion, Helicobacter pylori infection, the use of non-steroidal anti-inflammatory drugs, irregular life and diet, work and external stress, smoking, drinking and mental and psychological factors. The clinical manifestations of duodenal ulcer include chronic, periodic, rhythmic epigastric pain, which can last for days, weeks or even longer, mostly during hunger and relieved after eating, and some patients have nocturnal pain and are often woken up by pain. Commonly used drugs for the treatment of duodenal ulcer include omeprazole and cimetidine, and Helicobacter pylori infection can be eradicated with a quadruple method, i.e., one proton pump inhibitor such as omeprazole + one bismuth such as felicific bismuth + two antibiotics such as amoxicillin and clarithromycin. Patients are advised to go to the hospital in time and use the drugs under the guidance of the doctor.