Drug-related kidney damage refers to a type of disease in which various drugs cause kidney damage, including Chinese and Western medicines. The kidneys are often an important organ for drug metabolism and excretion. Excessive use of drugs can cause kidney damage, nephrotoxic reactions, and allergic reactions. Nowadays, drug-related kidney damage is happening more and more, which should be taken seriously. Because the normal kidney is rich in blood flow, a large amount of drugs will enter the kidney, and the surface area of the capillaries in the kidney is relatively large, which is prone to the deposition of antigen-antibody complexes, and the kidney has the highest concentration of drug excretion. Some drugs act on the renal tubules and then reabsorb, which may affect the kidney function and cause kidney damage. The kidney is more sensitive to ischemia and hypoxia because of its high oxygen consumption, so drugs that affect blood flow are also more sensitive, which can lead to increased susceptibility and cause kidney damage. The main drugs that commonly cause damage are antibiotics, aminoglycosides or tetracyclines, vancomycin, all of which are more damaging to the kidney; there are also aspirin and some painkillers that have a greater impact on the kidney; there are also contrast agents and anti-tumor drugs; there are also some Chinese medicines, aristolochia, mucuna pruriens, huperzine and motherwort, which also identify the kidney damage is more serious.