Patients with glycosuria who have progressed to stage V or VI, with neovascularization and fibroplasia in the fundus, will have significant vision loss and will undergo vitrectomy, or biosurgery for short. What exactly is vitrectomy? How does it treat the glycosuria? What are the risks of the procedure? What is a vitrectomy? How does it treat the glycosuria? If you compare the eye to a room, the retina is the wall of the house. The walls are clean for patients without glycogen reticulum, but once you have glycogen reticulum, some stains (blebs) will appear on the walls, and the stains will gradually expand and damage the walls; slowly many spider webs (neovascularization) will grow on the walls, and these spider web-like neovascularization will pull the walls, or even pull the walls down, which is actually the occurrence of retinal detachment. At this point, a vitrectomy is done with the goal of going into the room, cutting the cobwebs clean, and then resetting the detached wall. The surgery involves making 3 eyes in the eye: one eye to put a tube to constantly pour water into the eye to prevent it from deflating; the other two eyes, one to place a searchlight for illumination and the other to put surgical instruments, such as forceps and scissors. Should I put something into the eye for biosurgery? Many patients may have heard that they have to pump oil or air into their eyes after biosurgery. In fact, after biosurgery, if there is no crack or bleeding in the retina, there is no need to pump anything, but only if there is a crack in the retina. The reason why we need to pump air or oil is that after the retina is reset, using air or oil to hold up the eye can make the retina fit better with the inner wall of the eye. It’s like tiling a tile, you have to press it for a while to make it stick firmly. However, it is up to the surgeon to decide whether to apply air or oil at the time of surgery. If the retinal fissure is particularly large and numerous, the bleeding is heavy, and the retina is not very easy to reset, it needs to be propped up for a longer time and then oiled, because the gas is absorbed after about two weeks. Many patients are worried that the surgery is too risky, and they always put it off again and again and are not willing to do it. It is true that there are risks in biosurgery, but with the development of medical technology and the increase of doctors’ experience, the risks of surgery are much reduced. Or the above analogy, if there are cobwebs in one corner of the room and the wall is only a little bit broken, the surgery is naturally good and the risk is small; but if the room is full of cobwebs and the wall is all broken, the surgery is relatively much harder. Therefore, for patients, the most critical thing is to seek medical attention as early as possible, early detection and early treatment.