Toothpaste plus whatever you use cannot achieve the effect of removing spots in clinical practice. The spots on the face are actually due to the excessive production of melanin, and the application of toothpaste as well as daily necessities cannot do anything to remove the melanin in the skin. Its formation has a great relationship with sunlight, emotion, diet and especially hormone level. If you want to treat it, you must go to a regular hospital. The most commonly used clinical treatment for hyperpigmentation is actually laser cosmetic and fruit acid peels. It can also be treated with topical medications, such as hydroquinone cream. It is important to pay attention to sun protection, wear a hat and umbrella when you go out, and apply sunscreen if necessary.