Pimples on the face are generally referred to as acne. Sudden acne on the face can be caused by physiological hormonal changes, but also due to endocrine diseases, the use of hormone-containing drugs, or the lowering of the body’s immunity. 1. Physiological hormonal changes: (1) Adolescents: androgen secretion increases, resulting in a surge of acne, commonly known as “pimples”, which will gradually subside with the end of puberty. (2) pregnancy crowd: the female body sex hormone changes during pregnancy, can cause long acne. (2) Endocrine diseases: such as polycystic ovary syndrome, can cause abnormal secretion of sex hormones, oil secretion, resulting in the occurrence of acne. 3. Use of hormone-containing drugs: long-term and high-dose oral or topical hormones, can lead to acne, can be discontinued through the use of hormones or the addition of drug intervention, such as isotretinoin gel, need to choose the appropriate program under the guidance of a doctor. 4. Decreased immunity: When the body’s immunity decreases, it is easy to cause bacterial reproduction, such as Propionibacterium acnes, causing acne, which can be improved by oral minocycline capsules and topical clindamycin phosphate gel. When the above factors exist, you need to go to the regular hospital in time, by the doctor to clarify the cause of the disease, give targeted treatment. The above medications should be used in accordance with medical advice.