Gamma-glutamyl transpeptidase refers to the enzyme gamma-glutamyl transpeptidase, and a high level of this test indicates possible liver, gallbladder, pancreatic, or urinary tract disease. Gamma-glutamyl transpeptidase is widely distributed in the kidneys, liver and pancreas. If these organs are damaged, the cells will be necrotic and lysed, and gamma-glutamyl transpeptidase will be released into the bloodstream, causing its levels to increase significantly. Elevated gamma-glutamyl transpeptidase is more common in biliary obstructive diseases, such as primary biliary cirrhosis and sclerosing cholangitis, where values can reach more than 10 times the upper limit of the normal range. Elevated gamma-glutamyl transpeptidase levels are also detected in acute and chronic viral hepatitis and alcoholic hepatitis, while elevated gamma-glutamyl transpeptidase is also seen in pancreatitis and prostate tumors. After detecting elevated gamma-glutamyl transpeptidase, seek medical attention in a timely manner and undergo ultrasound, CT, magnetic resonance imaging and other ancillary tests to further clarify the condition and then administer the correct treatment.