Squamous cell carcinoma, referred to as squamous carcinoma, also known as epidermoid carcinoma, is a malignant tumor that occurs in the cells of the epidermis or appendages. The cancer cells have different degrees of keratinization. Squamous cell carcinoma of the skin is a red, hard nodule in the early stage, which later develops into wart-like or cauliflower-like damage invasion, often with ulcers, purulent discharge, and foul odor, and is most commonly found on the temporal region, forehead, and lower lip. Squamous cell carcinoma needs to be diagnosed by taking tissues from the lesion for pathologic examination. Surgical resection of squamous cell carcinoma is the mainstay, with extended radical resection, skin grafting or flap repair in the early stages. For middle and late stage squamous cell carcinoma, surgery plus radiotherapy and chemotherapy are needed for comprehensive treatment. For squamous cell carcinoma, surgical resection is sufficient if it is found in early stage. For middle and advanced stage patients with metastasis, surgical resection plus radiotherapy and chemotherapy are needed for comprehensive treatment.