Instructions for the treatment of patients with intestinal obstruction or intestinal fistula (chronic radiation enteritis) after radiation therapy

Patients with chronic radiation enteritis is one of the intestinal complications resulting from radiotherapy for abdominal, pelvic and retroperitoneal tumors, which can accumulate in the small intestine, and rectum. Its detection rate is around 8%, mostly seen after radiotherapy for gynecological and colorectal malignancies. The clinical manifestations are mainly recurrent abdominal pain, diarrhea, blood in stool, and in severe cases, intestinal obstruction, intestinal perforation and intestinal fistula. Due to the tumor burden, repeated radiotherapy and subsequent intestinal complications, patients with radiation enteritis often suffer from severe malnutrition, anemia and organ insufficiency, and their unique pathophysiological changes of radiation injury lead to decreased healing ability of tissues and extensive dense scarring adhesions in the abdominopelvic cavity, forming a “frozen abdomen” or “frozen pelvis”. The unique pathophysiological changes of radiation injury lead to decreased tissue healing ability and extensive dense scarring adhesions in the abdominopelvic cavity, forming a “frozen abdominal cavity” or “frozen pelvic cavity”, which is extremely difficult to operate, with many postoperative complications and high mortality rate. For patients who suffer from it, it is especially important to get more timely and professional treatment. The diagnosis and treatment of chronic radiation enteritis is relatively simple: first, there is a history of tumor, received systemic or local radiation therapy; second, the appearance of gastrointestinal symptoms, such as: diarrhea, bleeding, ulcers, abdominal pain, obstruction, intestinal fistula and intestinal perforation; chronic radiation enteritis treatment is currently based on nutritional support, drugs and surgery. About 1/3 of patients with chronic radiation enteritis require surgical intervention, with intestinal obstruction, bleeding uncontrolled by internal medicine, abdominal infection and intestinal fistula as indications for surgical intervention. In chronic radiation enteritis, due to radiation therapy, the intestinal wall is altered by small-vessel endarteritis and fibrosis, and the area irradiated by radiation will form a scar between the intestinal tubes, which is called “frozen pelvis” or “pie-like fusion” in the industry. It is extremely difficult to separate the adhesions between the intestines and the risk of reoccurrence of the anastomosis is very high. On the one hand, this type of disease is often mistakenly treated as adhesive intestinal obstruction, and surgeons lack knowledge of the poor healing ability of radiologically damaged intestines and lack psychological preparation for the difficulty of surgery, which often results in catastrophic consequences for the patient; on the other hand, surgeons who have had difficult surgical experience and “catastrophic consequences” are On the other hand, surgeons who have had difficult surgical experiences and “catastrophic consequences” are “afraid of this disease like a tiger”.      The unique preoperative evaluation and surgical strategy, precise surgical techniques to separate the “frozen pelvis”, placing the anastomosis in a site that has not been damaged by radiation, unique large caliber lateral anastomosis technique, effective fistula prevention techniques and perioperative nutritional support are the key aspects to the success of this type of surgery. The unique large-bore lateral anastomosis technique, effective fistula prevention techniques and perioperative nutritional support are key aspects of successful surgery. Please be sure to bring all medical records (especially surgical records, pathology results, radiotherapy cases) and relevant tests and imaging data (abdominopelvic enhanced CT, total gastrointestinal tract imaging, sinus tract imaging, Pet-CT, etc.) before your visit. The medical records of each hospitalization can be copied from the case room of the original hospital, and the imaging data can be obtained from the doctor in charge of the hospital at the time of discharge. 2. Please organize the patient’s course of illness and treatment and surgery in chronological order, so as to quickly, accurately and comprehensively show the development of the disease. (1) Tumor history and surgery history: What kind of tumor was diagnosed and treated in a hospital with surgery records; postoperative pathology: XX cancer (see pathology report) and pathological stage; if there is no surgery history, you can skip this item. (2) History of postoperative radiotherapy, including: time, mode, dose and frequency of radiotherapy, side effects during radiotherapy, and the presence of concurrent chemotherapy, for example: 50 Gy pelvic radiotherapy was administered in XX months of 20XX (from XX days after surgery) for a total of 25 times, mild diarrhea and leukocytopenia occurred during radiotherapy, which were treated symptomatically. (3) history of obstruction, intestinal fistula or bleeding: for example, 1 year after radiotherapy, abdominal pain and distension, mainly in the lower abdomen, with colic, and a mass-like elevation in the abdomen, and at the same time, a sound of intestinal tones could be heard, and intestinal obstruction was considered, and the patient was consulted at the local hospital. After conservative treatment or surgical treatment (with surgical records), the symptoms gradually worsened, and the obstruction episodes increased from once a month to once every half a month, and the period of episodes gradually extended. Li Yuanxin, chief physician of the general surgery department of the 309th PLA Hospital, studied and worked in the Institute of General Surgery of the Nanjing General Hospital of the Nanjing Military Region for nearly 20 years under the guidance of academician Li, who treated a large number of complex gastrointestinal surgery patients from all over the country, formed a unique separation of severe abdominal adhesions, intestinal fistula abdominal He has developed distinctive and difficult technical features such as unique separation of severe abdominal adhesions, abdominal infection drainage and digestive tract reconstruction techniques, minimally invasive laparoscopic surgery techniques, small bowel transplantation and abdominal multi-organ cluster transplantation techniques and surgical nutrition support. Small bowel transplantation and abdominal multi-organ cluster transplantation are the pinnacle of gastrointestinal surgery technology. Professor Li Yuanxin was introduced into the second ward of general surgery of the 309th PLA Hospital in 2012 as the leader of the discipline, and has formed the main technical characteristics of complex intestinal obstruction, intestinal fistula and radiation enteritis, which is well-known in the industry. The relevant research has been reported by CCTV 10 (http:///zhuanjiaguandian/liyuanxin_1820748573.htm) and Xinhua (http://news.xinhuanet.com/mil/2014-). (09/02/c_126942487.htm). The related research was funded by an independent sub-project of the National Army Medical Major Project. Director Li Yuanxin’s clinic hours are every Friday morning, located on the second floor of the outpatient building of 309 Hospital in the surgical area; you can pay attention to 309 Hospital’s official website and doctor’s webpage to make an appointment and get information about clinic closure and clinic time change in advance; in order for you to get the latest consultation information, more timely treatment and more professional pre- and post-operative health guidance, you can join Director Li Yuanxin’s personal doctor’s website:. We wish all intestinal fistula patients a speedy recovery! PLA No. 309 Hospital, General Surgery Department No. 2