As all sugar lovers who take medication regularly know, diabetes requires regular medication, but due to one problem or another, they may forget to take their medication, so is it necessary to take a refill? This depends on the type of medication, some can be supplemented, some do not need to be supplemented. 1, insulin secretagogue: Glipizide, Glimepiride, Gliclazide, Repaglinide, Naglinide, etc.. The main is to stimulate the secretion of insulin, to achieve the effect of lowering sugar, if the post-prandial and then replenishment of the case, blood sugar levels gradually decline, the role of drugs gradually enhanced, easy to cause instability, or hypoglycemia. 2.Biguanide: metformin, phenibut. Mainly to enhance muscle, fat and other peripheral tissues to the uptake and utilization of blood sugar, to play a role in lowering sugar. Taken after the meal, can reduce the stimulation of the stomach and intestines, but if the wrong 1 hour, but also add other drugs, will also cause low blood sugar, hypoglycemia. So don’t take it 1 hour after the wrong time. 3, glycosidase inhibitors: Acarbose, voglibose. Mainly by inhibiting the absorption of carbohydrates in the small intestine, reduce the postprandial blood sugar. If the post-prandial supplement, the effect is discounted significantly. 4.Thiazolidinedione, DDD-4 preparations: pioglitazone, saxagliptin, sitagliptin. These drugs are not related to meals, so you do not need to care about before and after meals, you can take them at any time. In short, glucose-lowering drugs, due to the different mechanisms, miss the time to take the medicine to make up for it, will affect the effect of the drug, and even serious will cause the occurrence of hypoglycemia situation. Therefore, it is important to pay attention to the supplementation.