Hand and foot syndrome is a skin toxicity caused by chemotherapeutic drugs. Clinical manifestations are progressive aggravation of skin lesions, mainly itching, pain, erythema, and dull sensation of the skin of the palms and soles of the feet, etc. Basic nursing care is usually used to alleviate the symptoms, which can be combined with drug treatment. 1. Basic care: avoid prolonged friction, extrusion and contact with hot water on hands and feet, and wear gloves when washing things to reduce the damage. Normally, hands and feet can be placed to a higher position, avoiding strenuous exercise and heavy labor. In addition, diet should avoid spicy, stimulating food. 2. Medication: If pain occurs, you can take non-steroidal anti-inflammatory analgesic drugs such as ibuprofen and celecoxib. Vitamin B6 can also be taken. If skin infection occurs, erythromycin ointment and mupirocin ointment can be used externally. Hand-foot syndrome is mainly based on basic care, if you need to use drugs, you should strictly follow the doctor’s instructions to use, not to be used indiscriminately, so as not to lead to adverse consequences.