During pregnancy preparation, you need to take one tablet of folic acid per day, the size is 0.4 mg per tablet, and both spouses need to take it. Women should take it at least until the third trimester to prevent fetal neural tube abnormalities and premature births, and eat more folic acid-rich animal liver, dark green vegetables and beans. During pregnancy preparation, it is important to quit smoking and drinking, avoid overwork and staying up late, and enhance the intake of nutrition, especially high-quality protein, to avoid malnutrition that may affect the development of the fetus. Both spouses need to undergo physical examination to prepare for pregnancy, pay attention to exercise, enhance physical fitness, improve immunity and try to avoid infections, which can lead to fetal infections during early pregnancy.